Bipolar Depression - A trial of an add-on probiotic to prevent relapse and improve the clinical course after hospitalization for bipolar depression

This study is seeking volunteers for a clinical trial that may help prevent readmission for an exacerbation of psychiatric symptoms. Participants take add-on probiotics or placebo for 24 weeks and are compensated for their time. 

Probiotic supplements contain tiny healthy organisms similar to those found in breast milk, yogurt, and some other foods. They are thought to provide health benefits by improving digestion and modulating the immune response.  


  • Are currently or recently admitted to an inpatient or day hospital program for symptoms of bipolar depression, and with a diagnosis of Bipolar I or II disorder
  • 18 - 65 years old
  • Available for follow-up phone calls weekly and in-person visits every four weeks at Sheppard Pratt's Towson campus during a 24-week treatment period

PI: Faith Dickerson, PhD, MPH

Founding source: Stanley Medical Research Institute

To participate, email Emily Katsafanas or call 410-938-4360.

Learn more about this study.

Major Depressive Disorder - Psilocybin

This study will evaluate the optimal dose of psilocybin, administered under supportive conditions to adults with treatment resistant depression, in improving depressive symptoms.

Eligibility: We are currently seeking participants ages 18 to 54 at screening to enroll in this outpatient study. Participants must have a current depressive episode duration of  ≥3 months and ≤2 years. Participants must also have had 2 to 4 pharmacological treatment failures at adequate dose and duration. 

PI: Scott Aaronson, MD

Sponsor: COMPASS Pathways, Ltd.

To participate in this study, email Tammy Miller at or call 410-938-3141.

Learn more about this study.